To maintain the full health of the human body, including the skin, all planned by organism processes must take place in it. This mechanism could function without interruptions only if the body were perfectly healthy, no harmful substances were in it, and no destructive processes were taking place in it. A man could not be subject to stress, would always have to sleep perfectly, perform particular physical activity, eat only healthy products, breathe clean air, drink perfect water, and have an ideal genotype. And even that would not be enough because, in evolution, there have been many mistakes, and all eukaryotes have some wrong mechanisms (e.g., lack of production of vitamin C in the human liver). In addition, evolution invented a way to eliminate all living organisms that have passed the fertility age. All individuals that have already produced offspring are unnecessary and even harmful for evolutionary purposes. This is why, after the age of 25-30, a decrease in the synthesis of all substances and the efficiency of defense mechanisms and general aging of the body begin. If you look at any species, you will observe exactly the same pattern. However, man is intelligent and can deal with hostile processes to some extent. Regarding caring for a healthy appearance, we humans already have some knowledge. Still, now and then, we learn about entirely new mechanisms, about the new meaning of substances discovered in the past, and we try to increase awareness of who we are and how our organism is. Our laboratory has been following this path for many years. It cooperates with many research institutions to stay up to date with the latest scientific reports to be able to implement these solutions in our lives. This is how a unique product was created, combining nature and the latest biochemical engineering.

Collagen DNA is a cosmetic that is ahead of today's cosmetology. Yet, such cosmetics are not even discussed in professional beauty salons, dermatological offices, or universities. Why? Because there are no such cosmetics.

All these threats affect us daily, which deteriorates our body's condition and quality of life. When it comes to our skin, these threats cause the most significant human organ to age the fastest. Not only is it not perfectly nourished from the inside (improper diet), but it is most damaged from the outside - the so-called photoaging of the skin.

Skin depreciation starts with two reasons:

– poor moisturizing and greasing from the outside causes loss of skin cement – microcracks in the lipid coat through which epidermal water escapes

– the action of free oxygen radicals. They cause cell damage and DNA and RNA damage. As a result, cells die faster and pass on wrong information to other cells.

Then the consequences of these causes are like a chain reaction - one goes bad, it spoils the next, and the next break the third... Cells shrivel, lose their cytoplasm, sprout and die too early.

The best active ingredients can be used, but if we do not take care of the proper functioning of the mechanisms at the cellular level, this fight will be less effective. Therefore, DNA repair and protection is the most crucial element in the battle to maintain a healthy appearance of the skin. The body, of course, has the ability to repair its nucleic acids, but these mechanisms are also disturbed, degraded, and constantly subjected to oxidative stress.

Without the production and maintenance of the right amount of healthy cells, neither the right amount of collagen, elastin, hyaluronic acid, fibronectin, nor other "building blocks" of our skin will be built.

The role of DNA collagen, apart from the beneficial effects of collagen itself, is to ensure that all the mechanisms planned by the body related to the skin's structure run smoothly. DNA collagen is designed to secure the correct processes, intensify their activity, and even stimulate the appropriate cells for planned activities. So what if we give the best ingredients that increase synthesis if, for example, free radicals will destroy newly formed cells? It's like pouring water into a sieve.

All cosmetics act on the intercellular space (extracellular matrix), where collagen, elastin, hyaluronic acid, glycosaminoglycans, etc., are located. However, apart from antioxidants, cosmetics have nothing to do with the effect on the cells themselves.

It is said that by stimulating collagen production, there will be more of it, and the skin will be firmer.

It's only a half-truth. Why? If we have too few cells that have undergone apoptosis too quickly for many different reasons, no matter how much we build the intercellular space, we will not get "dense" skin, cross-linked and healthy.

Hence, the idea behind the composition of collagen DNA was to create a cosmetic that would act both on the intercellular space, effectively stimulating collagen synthesis, and on the cells themselves, helping them to protect themselves from reactive oxygen species, allowing them to regenerate after the attack of free radicals, creating better conditions for their regeneration, multiplication and finally cause that there will be more of them and they will work properly.

Therefore, a cosmetic was created designed to protect and regulate processes at the cellular level. Research on the final recipe lasted 3.5 years.

DNA collagen is used to protect cells and their DNA from:

– by-products of mitochondria, which are reactive oxygen species,

– photoaging,

– the action of UV rays and the free radicals produced,

– oxidative stress,

– various metabolic processes,

- neutralizing toxins

However, the action of DNA collagen is also:

– increasing the synthesis of collagen and other building blocks of our skin,

– cell activation

– peripheral vasodilation (circulatory patency)

– improvement of lipid metabolism

– increasing HDL cholesterol levels

– reduction of LDL cholesterol

– increasing the synthesis of ATP (nucleotide, which is responsible for transferring the necessary energy, among others, for cell division and various biosynthesis. Without energy, these processes will not take place).

– faster recovery of the skin to its normal/proper condition.

Collagen DNA is a gel in which, apart from the collagen itself, there are active substances:

– deoxyribonucleic acids (DNA)

– ribonucleic acids (RNA)

– kinetin

– superoxide dismutase

– GHK-Cu copper peptide

– rose placenta extract

DNA+RNA nucleic acids (native)

Nissei Bio - our Japanese supplier of native salmon milk extract, has patented a unique technology for the purification of nucleic acids from any other substances and impurities, obtaining a deoxyribonucleic acid (DNA) content of 70%, very rich in protamine and histones.

Salmon milk extract is a substance that activates cells to multiply. This is because histones regulate the density of chromatin. Tightly packed chromatin (heterochromatin) makes it difficult to access the genetic material. Therefore, the cell must have a looser chromatin structure (euchromatin) when preparing for division. The action of these substances supports/facilitates cell replication (multiplication).

In addition, nucleic acids have a strong antioxidant effect, protecting cells against reactive oxygen species. They protect against destructive toxins such as dioxins, benzopyrene, and hundreds of other pollutants that get to us either from the air or even those that the body produces itself as side effects of various processes. Toxins act directly on the double helix of the genotype, destroying its structure. DNA and RNA acids are a kind of filter for toxins, protecting our cellular system.

DNA and RNA also dilate peripheral vessels and unblock circulation, thus oxygenating cells. Cell hypoxia is dangerous and carcinogenic. In hypoxic cells, the processes that are supposed to occur are disturbed, and the cytoplasm's acidity decreases; this is a suitable environment for anaerobes, such as cancer cells.

Nucleic acids improve lipid metabolism. Disruption of this process leads to atopic dermatitis, a malfunction of the lipid barrier, resulting in dry skin.

A significant role of DNA is to increase the synthesis of our chemical energy ATP (nucleotide adenosine triphosphate, which is responsible for transferring the necessary energy, among others, for cell division and various biosynthesis. Without energy, these processes do not take place).

Nissei Bio - has done a lot of research, which shows that these acids have a very positive result in improving skin quality. We present the results of research on a group of patients:

 

 

KINETHINE

– Stimulates DNA repair processes

– Extends the life of fibroblasts until their natural (unaccelerated) apoptosis process

– A strong inhibitor (blocker) of oxidation and glycosylation processes of proteins and nucleic acids
– Improves the barrier functions of the spinous layer
– Kinetin forms complex compounds with copper ions – it is ideal in combination with the GHK-Cu and SOD peptide
– Kinetin does not cause side effects or skin irritation

In Collagen DNA, a non-standard substance has been introduced. Kinetin is just that for many reasons. But first, we must say at the beginning that Kinetin does not dissolve in water. And yet we made it.

KINETHIN (cytokine N-6-Furfuryladenine) is the only substance that connects people with plants. It is a growth hormone, which is also present in the human genetic code, stimulates DNA repair processes, protects against UV rays and free radicals, and reduces excessive pigmentation. It improves the skin's structure and causes collagen and elastin fibers to regain their proper weaving density. In addition, Kinetin stimulates the proliferation of proteins. As a growth hormone administered to the skin, it is a specific booster of peptide synthesis mechanisms.

A crucial role of kinetin is the ability to extend the life of fibroblasts. Due to its chemical structure, it has an affinity for DNA, thanks to which it stimulates its repair mechanisms. This causes kinetin to prolong cell life, helps smooth the skin, improves its color, and reduces surface wrinkles.

Kinetin is considered a strong inhibitor (blocker) of the oxidation and glycosylation processes of proteins and nucleic acids. It is a strong antioxidant, both in vitro and in vivo, and it delays the aging processes of human cells in in vitro cell cultures. Kinetin affects the growth and shape of cells, their growth rate, the cytoskeleton structure, the synthesis of macromolecules, and lipofuscin content.

It has a beneficial effect on the skin, improves the barrier function of the spinous layer, reduces water loss through the epidermis (lower TEWL), and improves skin tone.

Kinetin also forms complex compounds with copper ions, which are a cofactor for SOD - Superoxide Dismutase.

Kinetin does not cause side effects or skin irritation, so that it can be safely used even by people with sensitive skin.

SOD – Superoxide dismutase

– Protecting the mitochondria, which produce the ATP energy necessary for life

– Completely eliminates oxidative stress

Super Oxide Dismutase - SOD - Super Oxide Dismutase is another substance that works at the cellular level. SOD remarkably protects cells against the degradation of DNA and RNA, as well as entire cellular structures.

It is the fastest enzyme of all known to man, which eliminates free oxygen radicals (Reactive Oxygen Species ROS) from the body.

Free radicals are unpaired molecules, very reactive.
Radicals with one electron will tend to pair with the other radical. However, no such pairing takes place.
Therefore, radicals look for any molecule in their vicinity to pair up and thus initiate a whole chain of reactions in which electrons are transferred.
Reactions of radicals with DNA, proteins, and lipids, and especially the accumulation of damaged biopolymers, trigger the beginning of degenerative processes, which may consequently lead to the development of many diseases and aging of the body.

Throughout life, there is constant oxidation and reduction in the body. The state of balance of the body's oxidation and its ability to reduce oxidation is called REDOX (Reducing Oxydation) balance.

In certain situations, the level of ROS can increase rapidly, leading to damage to the structures in the cells. This phenomenon is called oxidative stress. Cells defend themselves against it by increasing the expression of enzymes such as superoxide dismutase, catalase, and peroxidase.

Changes in ozone concentration, high and low temperature, UV, pollution, RNA breakdown, stress, and the effect of a dirty atmosphere - all cause oxidative stress.

Unfortunately, the work of the mitochondria itself is not perfect either. Our energy factories converting oxygen into chemical energy ATP - adenosine triphosphate - produce by-products, which are oxygen free radicals. Dismutase helps protect mitochondria from self-destruction. This plays a significant role in maintaining a healthy and good appearance. But, of course, dismutase does not protect only the skin - it works throughout the body.

Dismutase is the strongest antioxidant in the world (the speed of this enzyme is 500 million spins per second - the fastest known enzyme). No other substance can close unpaired oxygen bonds O2-, O2, HO2, and the worst form of OH- so effectively.
This is very effective and possible inside the body, but there is constant over-oxidation on the skin, and there is never a REDOX balance. ROS lead to cell mutations (lipids, proteins, and DNA), which transmit wrong signals to neighboring cells, which also mutate their very delicate DNA chains, causing them to malfunction. !! The cell loses water, shrinks, the DNA breaks down, the cell nucleus condenses, the cell loses contact with the substrate, and various protrusions form on its surface.
Free radicals transmit incorrect information to neighboring cells and their self-destruction occurs, i.e. accelerated apoptosis
The ultimate effects of free oxygen radicals in the cells of the body are: mutations, metabolic dysfunctions, aging.
What's worse, during an ROS attack, there is an energy deficit in the cell, and this can lead to cancerous changes.

The reaction in which OH- is formed, and in fact -OH (Fenton or Haber-Weiss reaction) looks like this O2 → O2• → H2O2 → •OH → H2O and is exothermic, so it releases heat energy in the form of ultraviolet radiation (gives off a quantum of energy). When a molecule absorbs this quantum, the electrons rearrange, and triplet oxygen is formed. Triplets, in turn, give rise to singlet oxygen.

Oxidative stress in a cell is a shift in the balance of oxidation and reduction towards oxidation.
Without oxygen, life in its present form could not exist. However, this essential element for living cells can be a source of reactive oxygen species (ROS).

Superoxide dismutase is there to effectively and safely deactivate all ROS. It reduces and even eliminates oxidative stress.

Dysmutase is the first line of defense of the whole organism against free radicals. It is the most powerful weapon in the world against these aggressive oxygen molecules.

Copper peptide GHK-Cu ((very) blue peptide)

– Stimulation of stem cells,

– Increases the production of collagen in the skin
– Prevents photoaging much more strongly than Vit. C or retinol.
– Significantly improves skin elasticity,
– Unifies the skin tone and its appearance,
– Reduction of the depth of wrinkles and increases the density of the skin and its thickness
– Repairs cell membranes that have been damaged by free radicals, toxins and other degradation processes.
– Anti-inflammatory effect
– Stimulates the proliferation of keratinocytes, which has been confirmed in histopathological tests
– GHK-Cu is non-toxic and does not cause skin irritation

– Copper is a cofactor for SOD

 

You have to imagine what role this peptide has in our body.

Our entire body consists of about 50-60 trillion cells. On average, each cell is attacked by free radicals a million times a day. The GHK-Cu peptide is the most important tool for this process.

How effective does it have to be?

50 trillion times 1 million is 50 trillion repair operations in one day. It is counted in the SI nomenclature (million, billion, trillion, quadrillion). If you call it in the Anglo-Saxon system, there are 50 quintillion of these processes.

It would be good if our bodies were 100% efficient. But, unfortunately, this is never the case – even in people who are bursting with health. In addition, the synthesis (production) of virtually all active substances decreases with age, so the efficiency of processes decreases.

Destruction of the skin causes its degradation. However, it would be less if the body could repair it more efficiently. This is the main reason the GHK-Cu peptide is contained in DNA collagen.

ROSE PLACENTA EXTRACT

An extremely expensive ingredient that can be found in the most exclusive cosmetics in the world. It has a strong antioxidant effect (contains terpenes, glycosides, flavonoids, and anthocyanins), protecting the skin from the effects of reactive oxygen species. It stimulates the epidermal growth factor EGF (Epidermal Growth Factor) and the transforming growth factor TGF - β1 (Transforming Growth Factor β1), which performs many different functions, controlling cell growth, proliferation, differentiation, and apoptosis. It activates keratinocytes in the skin and accelerates its regeneration. In this way, it supports the skin's metabolism and promotes its reproduction. It helps reduce the amount of melanin produced by the skin, making it appear brighter and more even.

The rose placenta in this product comes from Japan and is extracted from the best variety of Bulgarian roses, Rosa Damascena.

To sum up - COLLAGEN DNA works on the full spectrum of the skin. It works on the intercellular matrix and the cells themselves, protecting them against many degradation processes (e.g., oxidative stress, glycosylation of proteins and nucleic acids, etc.), repairing their damage, helping them to multiply, and helping to bring the state closer to homeostasis.

This is a cosmetic that has been called DNA - not because it sounds nice, but because it really works at the cellular level.